Identification of functional anti-Staphylococcus aureus antibodies by sequencing patient plasmablast antibody repertoires

نویسندگان

  • Daniel R. Lu
  • Yann-Chong Tan
  • Sarah Kongpachith
  • Xiaoyong Cai
  • Emily A. Stein
  • Tamsin M. Lindstrom
  • Jeremy Sokolove
  • William H. Robinson
چکیده

Please cite this article as: D.R. Lu, et a antibody repertoires..., Clin. Immuno R E C

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Barcode-enabled sequencing of plasmablast antibody repertoires in rheumatoid arthritis.

OBJECTIVE A hallmark of rheumatoid arthritis (RA) is the production of autoantibodies, including anti-citrullinated protein antibodies (ACPAs). Nevertheless, the specific targets of these autoantibodies remain incompletely defined. During an immune response, B cells specific for the inciting antigen(s) are activated and differentiate into plasmablasts, which are released into the blood. We unde...

متن کامل

Construction of Human Recombinant ScFv Phage Libraries from the Advanced Stages of Breast Carcinoma Patients

Advances in the field of antibody engineering, and the emergence of powerful screening technology such as filamentous phage display allowed to generate fully human antibodies with high affinities against virtually any desired target from immune or even naIve human repertoires. As a result, the immunogenicity problems related to applications of nonhuman based recombinant antibodies as therapeuti...

متن کامل

Elevated IgA Plasmablast Levels in Subjects at Risk of Developing Rheumatoid Arthritis.

OBJECTIVE The disease process in rheumatoid arthritis (RA) starts years before the clinical diagnosis is made, and elevated levels of disease-specific autoantibodies can be detected during this period. Early responses to known or novel autoantigens likely drive the eventual production of pathogenic autoimmunity. Importantly, the presence of disease-specific autoantibodies can identify individua...

متن کامل

Comparison of antibody repertoires against Staphylococcus aureus in healthy individuals and in acutely infected patients.

The management of staphylococcal diseases is increasingly difficult with present medical approaches. Preventive and therapeutic vaccination is considered to be a promising alternative; however, little is known about immune correlates of protection and disease susceptibility. To better understand the immune recognition of Staphylococcus aureus by the human host, we studied the antistaphylococcal...

متن کامل

Functional antibodies targeting IsaA of Staphylococcus aureus

Functional antibodies targeting IsaA of staphylococcus aureus augment host immune response and open new perspectives for antibacterial therapy ABSTRACT 51 Staphylococcus aureus is the most common cause of nosocomial infections. Multiple 52 antibiotic resistance and severe clinical outcomes provide a strong rationale for 53 development of immunoglobulin-based strategies. Traditionally, novel imm...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014